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Using the friction cost method for valuation of productivity losses, the adjusted incremental cost was similar to that found by the human capital method, resulting in a similar incremental cost-effectiveness ratio as in the main analysis (tables 2 and 3).
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Comparing the variables created by the factor analysis in Table 7 with the variables presented in the main analysis (Table 2 in the main part of the paper), we see that the two sets of variables are quite similar.
There were 3 categories for mucinous feature (0%, 1 49%, and ≥50%) in the initial main analysis (Table 2).
There were 4 categories for stage (I, II, III and IV) in the initial main analysis (Table 2).
Sensitivity analyses considering the discovery and replication data of each GWA investigation as separate data yielded largely similar results as the main analysis (Table 2).
Matching was possible in 62 patients representing 43% of the patients considered in the main analysis (Table 4).
Analyses using creatinine-standardized metabolite concentrations (see Supplemental Material, Table S3) yielded results that were comparable with the main analysis (Table 3).
However, because of higher chlamydia prevalence in additional analysis, the estimated ICERs were substantially lower (<50%) than we found for main analysis (Table 3).
The first sensitivity analysis excluding patients who received neoadjuvant treatment yielded results comparable to those of the main analysis (Table 3).
Sensitivity analyses for the outpatient and non-outpatient claims for the entire cohort showed minimal differences compared to the main analysis (Table 1).
Among nonusers of lipid-lowering drugs with the longest duration of low LDL-C, comorbidities and medication use were less frequent than in the main analysis (Table S7).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com