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Although the main analysis suggested a similar efficacy of drug coated balloons and drug eluting stents, an exploratory subgroup analysis indicated a trend towards a risk reduction in target lesion revascularisation with second generation everolimus eluting stents.
The main analysis suggested that the cardioprotective benefit of total joint arthroplasty was most pronounced in the first four years of follow-up, after which the survival curves were essentially parallel.
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Findings similar to that in the main analysis suggest that competing risk bias is unlikely (Appendix Table 3, online).
Relative costs in the two-part sensitivity analysis were consistent with relative costs in the main analysis, suggesting that addition of €1 to all monthly costs in the main analysis did not materially affect the results (see Table 6).
Our sensitivity analysis restricted to white case and control subjects largely confirmed the findings in our main analysis, suggesting that ethnicity did not confound our findings (Supplementary Table 1).
A sensitivity analysis that used the previous year's manager gender category was not different from the main analysis, suggesting that the effect of employees changing managers or departments in response to an injury is minimal.
We also found a significant difference in participant-rated quality of life score in the main analysis, suggesting quality of life was worse in participants who were intensively followed-up.
When we repeated the analyses using NDVI measures obtained in August 2003 one of the driest summers in recent years results were consistent with those of the main analysis, suggesting that associations were robust against seasonal and year-to-year variation in vegetation.
However, adjustment for multiple pregnancies, socio-economic indicators and various immigration characteristics in our secondary analyses using Ontario data did not substantially change the associations observed in the main analysis, suggesting that residual confounding due to unmeasured covariates is rather small.
Some independent analysis suggests this may be right.
XRD analysis suggested that the main precipitated formed is K-jarosite.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com