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This analysis yielded RRs very similar to those in the main analysis (see Additional file 5).
An analysis comprising only alcohol use showed similar results as the main analysis (see Additional file 1: Table S1).
A total of 208 participants were included in the main analysis (see figure 1), of whom 148/207 (71.5%) were male and with a median age of 20.
Sensitivity analyses using different approaches to denominator extrapolation did not produce meaningful differences from the main analysis (see online supplementary tables S2 4).
4 23 Nevertheless, the analysis restricted to trials with independent adjudication of events supported the robustness of our main analysis (see web extra appendix 2).
Similarly, analyses without adjustment for blood lead were very similar to results of the main analysis (see Supplemental Material, Table S4).
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Based on these factorial results, for our main parametric fMRI analysis (see below), we grouped Wonder, Joy, and Power into a single class representing Vitality, that is, high Arousal and high Valence (A+V+); whereas Nostalgia, Peacefulness, Tenderness, and Transcendence were subsumed into another group corresponding to Sublimity, that is, low Arousal and high Valence (A−V+).
Therefore, all sites were pooled to obtain sufficient statistical power for the main analysis (but see Table S4 for an analysis per field).
For the decline-risk analysis (see main text and below), we obtained data on population trends between 1980 and 2004 for 4,027 of the 5,717 species (70%).
Ribosomal protein genes were excluded from the analysis (see main text).
Z7-16:Ald Z7-16 Aldded from the analysis, see main text for explanation.
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