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For the main analysis, cases and controls will be included if they have complete records for at least 2 years before the index date.
In the main analysis, cases were all individuals in the cohort experiencing death due to breast cancer during the study period starting from 3 months following breast cancer diagnosis.
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Following the case identification process, 142 cases in 138 GH-treated patients and 33 cases in 32 non GH-treated patients were included in the main analysis, with 176 cases in 172 GH-treated and 37 cases in 36 non GH-treated patients in the sensitivity analyses (Fig. 1).
Due to the small number of extrapleural mesotheliomas in the study population, we focused our main analysis on all cases of mesothelioma, irrespective of cancer site.
> -wrap-foot> Thepilepsysy cases were genotyped using a lower coverage array than the two wild-type control data sets used for this study (Illumina 660Q as opposed to Illumina 1.2 M), so for the main analysis we imputed case and control cohorts separately.
SCC, the most common histologic type of oropharyngeal cancer, accounted for 557 (94.7%) of all cases, and the main analysis was restricted to these cases (Table 2).
Analysis not adjusting for prognostic risk (dichotomous score) or white blood cell count allowed the inclusion of additional cases, especially the study from New Zealand, but results changed little compared with the main analysis (based on N=3315 cases).
The overall estimated SIR for evident cases (main analysis) was 0.88 (95% CI 0.74 1.04).
For the main analysis we included these two cases as re-infection cases and they were not counted as events.
Although our results are qualitatively insensitive to these assumptions, the quantitative results of our main analysis likely represent best-case scenarios.
Specifically, we halved and doubled the values used in the main analysis in each alternative case, with the exception of time horizon (10/20 years).
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