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The small risk is present in the main analysis, but the risks when comparing to a group with no history of ever using hormonal birth control is substantially larger.
The subgroup analysis showed no differences with the main analysis, but importantly there was no difference in occurrence of ARDS and blood pressure was lower in patients receiving higher PEEP compared to lower PEEP.
These patients were excluded from the main analysis but included in the sensitivity analysis.
We used the lag01 average for our main analysis but performed a sensitivity analysis on that choice.
This resulted in larger ICERs than in the main analysis, but the conclusion of the study did not change.
Disability due to defects arising during conception or embryogenesis will be excluded from the main analysis, but will be included in a sensitivity analysis.
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The cumulative total score (0 to 5) was used in the main analysis (modeling), but a three-level variable is presented for the purpose of descriptively highlighting the percentage of women with and without any stressor experienced during pregnancy.
The analysis for idiopathic cases (that is, with no risk associated conditions) and matched controls showed higher odds ratios for the oral contraceptives in the idiopathic analysis than the main analysis (table 4), but odds ratios by type of oral contraceptive were similar to the main analysis results.
This upregulation was not significant in the main analysis (FDR >10%), but we chose to follow up on this miRNA in later experiments because of its reported role in proliferation [ 38] and inflammation [ 39].
Patients diagnosed with endometrial cancer at death (n = 38) were excluded from the main analysis and tables but were included, with a survival time of one day and one year, in sensitivity analyses.
When comparing post-bariatric surgery births with matched control births of women who were eligible for bariatric surgery (body mass index ≥35; n=2496:12 126; mean body mass index 32.5 v 38.5; P<0.001), the excess risk of preterm birth observed in the main analysis was attenuated but remained increased (9.5% (236/2474) v 7.2% (863/12 027); risk difference 2.4%, 1.1% to 3.6%; P<0.001).
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