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The A1555G mitochondrial mutation is the main alteration associated with aminoglycoside-induced deafness.
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Although, CIMP+/MSI-and CIMP-/MSI-groups were equally hypomethylated for LINE-1, suggesting that microsatellite instability is the main molecular alteration associated with lack of LINE-1 hypomethylation.
Although we showed that a combination treatment is effective in modulating the main molecular alterations associated with acne, our study did not compare the effect of the combination product with that of each compound alone (i.e., nicotinamide, retinol, and 7-dehydrocholesterol alone).
These skeletal-muscle cultures can fully mimic the main biochemical and histological alterations associated with McArdle disease, including glycogen accumulation.
In addition, hypoadiponectinemia per se may not be the main issue in metabolic alterations associated with obesity.
Despite progress in identifying "hallmark" genetic alterations associated with the main subtypes of epithelial ovarian cancer, the survival rate of women with EOC changed little since platinum-based treatment was introduced more than 30 years ago.
Another main limitation of our study is that we used a peripheral white blood cell model to study the gene expression alterations associated with neuronal functions.
Genetic alterations associated with MA remain largely unknown.
Genes whose genomic alterations associated with drug sensitivity (Mann–Whitney U test, adjusted p < 0.1).
These alterations associated with high PGF2α expression.
Physiologic alterations associated with increased BMI affect the aminoglycoside PK.
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