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The phrase "main agents of" is correct and usable in written English.
It is typically used to refer to the main sources of a particular action or phenomenon. For example: "The main agents of social change in this community are the local youth organizations."
Exact(28)
"They don't like Indians because Indians were the main agents of the British occupation.
The existing public-health campaigns are directed at prostitutes as the main agents of infection.
Second, it presented the Portuguese and Brazilian upper class as the main agents of colonial rule and its inherent violence.
From the perspective of undocumented immigrants generally, it is unfortunate that Trump has settled on them as the main agents of this historic voter fraud.
Who selects what we see?" He started talking about how museums, which we thought of as the gateway to art, were actually the main agents of hiding art from the public.
These are the questions keeping biologist Fergus Watson up at night as he embarks upon research into "biofilms" – communities of microorganisms, thought to be one of the main agents of hospital super bugs.
Similar(32)
Clay is the main agent of adsorbtion.
The main agent of transformation, however, is Willington Wamayeye himself.
Management has been the main agent of this unprecedented transformation.
Then again, not everyone thinks the global economy will be the main agent of change.
The Holy Spirit is thus conceived as the main agent of humanity's restoration to its original natural state through Communion in Christ's body.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com