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Tobacco exposure is unquestionably the main aetiological factor in LC.
For all types, UV exposure is considered to be the main aetiological factor (Armstrong and Kricker, 2001).
Persistent infection with high risk Human papillomavirus (HPV) is the main aetiological factor in the development of cervical cancer.
Using microbiological, biochemical and molecular tools we have identified Edwardsiella sp. as the main aetiological factor of the disease.
This is in contrast to the West, where alcohol consumption is the main aetiological factor for liver cancer [ 37, 42].
To date, there have been no attempts to identify CNAs in lung tumours in which arsenic is thought to be the main aetiological factor.
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A review has been made of the main aetiological factors which have been related to colorectal cancer development with particular attention being focused on: a) new advancements in molecular biology, and b) the interaction between genetic predisposition and environmental factors.
Although the cause of preeclampsia remains unknown, three main aetiological factors are involved, namely immune maladaptation, placental ischemia and increased oxidative stress [29].
There are two main aetiological factors associated with increased risk of skin cancers: Ultraviolet radiation and immunosupression.
Intervention may occur as primary prevention through the identification of and decreasing exposure to the main aetiological factors, such as tobacco smoking and/or alcohol consumption, whereas secondary prevention may take place through screening programmes.
Current thinking supports the promotion of oral health through this approach since some of the main aetiological factors of oral diseases such as dental caries (high frequency and amount of sugar intake) are well-recognised as also being implicated in other conditions such as diabetes [ 6].
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