The question of the magnitude of replicative benefit, ideally measured in terms of replication rates in culture, is difficult to quantify using only published sequence data.
The extent of CPE induced by HSV is dependent on the magnitude of HPV replication and gene expression at the time of HSV infection.
As expected the magnitude of HIV replication was significantly lower in the control Jurkat cells compared to the control MT-2 cells (Fig. 8B).
There was a borderline (P = 0.02) correlation between magnitude of HSV replication and presence of HL-A type B-w44, but this does not explain the HD control difference.
Why JIO strains caused more severe hepatitis than might be expected for a genotype 3 virus is not clear, but the reason may depend on the magnitude of virus replication.
Mice were evaluated for permissiveness to infection by APMV serotypes 1 to 9, clinical disease, magnitude and location of replication in the respiratory tract, dissemination to other tissues, disease, histopathology, and induction of antibodies.
In this regard both SEA and the commercial cellular mitogen PHA exerted similar magnitudes of DNA replication in the studied controls within 7 days of culture.
Furthermore, the level of serum antibodies to HSV common antigen was not related to magnitude of in vitro replication.
Although replication of CMV, EBV and KSHV persists in many antiretroviral-suppressed, HIV-infected patients, we observed no evidence in this pilot case-control study that the magnitude of such human herpesvirus replication is associated with abnormally increased CD8+ T cell activation and sub-normal plateau absolute CD4+ T cell counts following virologically suppressive antiretroviral therapy.
In addition, many bacteria exhibit skewed base composition between the leading and lagging strands of replication, although the magnitude of this skew varies considerably among species.
