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Globalisation, for one, has increased the sense of peril.
Analysis of Peril expression levels confirmed the deletion of Peril.
10.7554/eLife.01749.006 Figure 2. Deletion of Peril leads to reduced viability.
In the case of Peril, no genes were found significantly differentially expressed in knockout vs wild-type brains within ±1 Mb of Peril.
To identify putative pathways affected by deletion of Peril, we performed RNA-sequencing on E18.5 brains from Peril −/− and wild-type littermates (n = 2).
Although generally safe, some of these interference strategies are not devoid of peril for the organism.
(B ) GSEA of Peril −/− vs wild-type E18.5 total brain RNA-Seq.
We observed that 50% (5/10) of Peril −/− pups died within 2 20 days after birth.
The magnitude of the losses?
The magnitude of it".
The magnitude of this gap is important.
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