Alternatively, one may estimate the depletion by measures of the predominant DA metabolite homovanillic acid (HVA) in cerebrospinal fluid in humans, but it is expected that the magnitude of DA depletion is larger than HVA depletion [ 5].
These results suggest that the difference of the background electron density affects the magnitude of TEC depletion.
To determine the magnitude of dopamine depletion induced by combined administration of reserpine and AMPT, 5 h and 10 h after the last i.p. injection animals were decapitate and their brains rapidly removed and the striatum dissected on ice and frozen at −80°C.
To assess the magnitude of volume depletion, percent weight loss and hematocrit were determined six hours after vehicle or furosemide injection.
Consistent with this, Nestin-CreER T2 ; Bmi-1fl/fl mice also had significantly lower frequencies of GEPCOTs than control mice at 6 months and 12 months after tamoxifen treatment, and the magnitude of the depletion increased over time.
These results show that two doses of MC-TG prolong MDSC depletion in the blood, that lower doses of MC-TG were effective at reducing MDSCs systemically and locally, and that the magnitude of MDSC depletion was dose dependent, with 10 mg/kg being the most effective dose.
If so, the magnitude of the depletion of the refuge population relative to the Bollgard II® population, along with the absolute kill of moths on Bollgard II® and subsequent opportunities for selection of the larval stage, will be critical in determining the relative frequencies of resistant insects in the population.
The former may be most appropriate to detect the presence of a lesion, whereas the latter is to be preferred to characterize the magnitude and extent of depletion in different animals.
The slopes of the lines relating the magnitudes of store depletion to Ca2 + entry did not differ significantly in relation to 9 cRA treatment (P = 0.222).
The depth and magnitude of regolith Na depletion increased continuously with increasing water availability, except for locations with mean annual temperature < 5 °C that exhibited little Na depletion, and locations with physical erosion rates < 20 g m− 2 yr− 1 that exhibited deep and complete regolith Na depletion.
