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Our analysis suggests that low magnitude expression changes may be of functional significance.
However, for the Hsf and Hsp100 protein families, the largest magnitude expression responses were associated with osmotic stress (Table 1).
The Hsp70, Hsp90, and Hsp100 protein families were generally associated with smaller magnitude expression responses across stress conditions.
These responses are largely independent of Alethea, although there is some evidence of an attenuation of the magnitude expression of salt-induced genes by Alethea pre-treatment.
While our approach here may have missed variation of low abundance transcripts and small magnitude expression differences, we identified numerous candidate genes for further study.
Stage I involved concept elicitation interviews with the target population to gather information regarding patient experience of influenza symptoms, including type, magnitude, expression, pattern of onset, and recovery.
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Order of magnitude expressions in the limit of small H/L and in the limit of large H/L were developed and then intersected to predict the optimal aspect ratio and maximum reaction rate.
It is important to note that, using the statistical test used by Hu et al., significant gene expression changes (both statistically and biologically) can be observed that have very low-magnitude expression changes (i.e., much less than twofold) (Hughes et al. 2000b), so low magnitude does not mean unimportant.
The network with the higher magnitude gene expression changes influenced cell cycle and gene expression.
This strategy allows the magnitude of expression to be estimated, rather than the relative expression level that is obtained from 'direct comparison' cDNA vs cDNA hybridisations.
Because both alleles are expressed at a relatively equal magnitude, the expression is biallelic.
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