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However, the common disadvantage of developed MNFHPs in overcoming the deposition problems is the extra-induced problem of magnetic manipulation resulting from unsuitable designs of either active or complex magnetic fields [11, 12].
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On the other hand, extrinsic magnetic manipulation technique uses cells conjugated with magnetically active external components, such as magnetic nanoparticles to enable manipulation.
Importantly, however, this experimental manipulation resulted in marked perceptual differences.
By safely incorporating MNPs into cellular spheroids, results demonstrated that JMCSs were capable of magnetic manipulation, and that magnetic forces used during magnetic force assembly mediate fusion into controlled patterns and complex tissues.
This experimental result will provide a new pathway to develop energy efficient magnetic manipulation techniques at the nanoscale.
Magnetic manipulation experiments are also demonstrated.
In the intrinsic magnetic manipulation technique, magnetic properties of iron-containing cells and biomolecules are harnessed to enable manipulation.
The major advantage of magnetic manipulation is "remote control".
Similarly, to other cell manipulation techniques, magnetic manipulation allows contactless positioning, sorting and trapping of cells and particles.
Magnetic manipulation of cells is enabled by utilizing intrinsic or extrinsic factors.
To further confirm our strategy, prototype palm-top sized device "magnetic manipulation device (MMD)" was designed.
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