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Deger et al. (2002) conducted a clinical study on the treatment of patients with localized prostate cancer with a magnetic hyperthermia, using self-regulating PdCo thermoseeds, after radiotherapy.
Biocompatible iron oxide nanoparticles for magnetic hyperthermia using polymers like poly ethylene glycol (PEG), poly vinyl pyrolidone (PVP), poly ethyleneimine (PEI), biomacromolecules like proteins, aptamers, DNA, and surfactants like CTAB are well reported [24, 25, 26].
Here, we present that the induction of HSPs by local magnetic hyperthermia using engineered superparamagnetic Mn0.5Zn0.5Fe2O4 nanoparticle agents (EMZF-SPNPAs) with a 5.5 nm mean particle size is promisingly feasible for a physiologically tolerable ocular neuroprotection modality.
The functionalized MNP presented here offer new prospects for optimizing tumor treatment by magnetic hyperthermia using MNP with high heating potential.
Here, we propose a strategy to improve the performance and the outcome of heat treatment for tumors by magnetic hyperthermia, using newly developed MNP that are functionalized through electrostatic interaction.
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Our purpose in this study was to investigate the usefulness of a method for controlling the temperature rise in magnetic hyperthermia (MH) using an external static magnetic field (SMF), and to derive an empirical equation for describing the energy dissipation of magnetic nanoparticles (MNPs) in the presence of both the alternating magnetic field (AMF) and SMF through phantom experiments.
A multivariate therapeutic strategy combining magnetic hyperthermia and chemotherapy using targeted, ligand-conjugated FIONs, could be an extension of our work.
Tumor cells can effectively be killed by heat, e.g. by using magnetic hyperthermia.
We aimed to improve magnetic hyperthermia of breast cancer by using innovative nanoparticles which display a high heating potential and are functionalized with a cell internalization and a chemotherapeutic agent to increase cell death.
In particular, magnetic NPs could be used as magnetic hyperthermia agents for the treatment of cancer [5,6].
Better biocompatibility for a bigger size is an added advantage, as FIONs have better magnetic properties to be used in magnetic hyperthermia experiments.
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