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In the various studies, differing amounts of magnesium were given to patients.
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Incidences of drug-induced arrhythmias when Magnesium is given concomitantly with inotropes or bronchodilators are nil.
Magnesium was given in 100%% of patients with eclampsia and was effective in controlling convulsions.
Magnesium was given to treat hypokalemia refractory and otherwise; patients responded very well.
It is noteworthy that in the ISIS-4 study, magnesium was given after reperfusion (iatrogenic or spontaneous), and this difference in timing might explain the negative result of the trial [ 124, 125].
1. Tachycardia induced by positive inotropes or cardiac pathology comes down to an acceptable rate when Magnesium is given in an average of 45 min. 2. Patients are protected from Tachyarrhythmia (Atrial and Ventricular arrhythmia).
Additional asthma therapies with aminophylline and magnesium sulphate were given on the discretion of the admitting team when asthma exacerbation was not responding to initial standard therapy after hospitalization.
The inconsistency of the study results might be explained by the different types and dosages of magnesium salts, which were given in the various trials as well as by the heterogeneity of the study populations.
A larger study randomized 47 chronic haemodialysis patients to two groups: a magnesium group in which patients were given oral magnesium citrate at a dosage of 610 mg every other day in addition to daily oral calcium acetate and a control group in which patients received only calcium acetate as a phosphate binder [ 75].
In many of these patients, oral supplementation was needed to normalize serum magnesium levels [ 45, 46], and in one study, oral magnesium supplements were insufficient and so 15% of patients were given magnesium sulphate in their PD fluid [ 46].
Out of 330 women at risk of preterm birth, 132 were given magnesium (132/330, 40%).
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