Statistically significant inverse trends in risk were observed in overweight subjects for colon and proximal colon cancer across increasing quintiles of magnesium uptake (P-trend, 0.05 and 0.02, respectively).
In humans, the bulk of systemic magnesium uptake occurs via the small intestine and is mediated by the action of the TRPM6 (and probably TRPM7) cation channels (reviewed in [1], [2]).
In the nematode, C. elegans, intestinal magnesium uptake is dependent on the activities of the TRPM channel proteins, GON-2 and GTL-1.
As it had only a slight impact on magnesium uptake and no influence on calcium and nickel uptake by the serpentine plants, the improved P nutrition seemed to be the crucial mechanism of the mycorrhizal promotion effect.
Magnesium uptake decreased in compost treatments compared to the control, whereas it increased in the 100%% compost treatment.
Consequently magnesium homeostasis, which depends on magnesium uptake in the intestine, magnesium storage in bone and magnesium excretion in the kidney, needs to be strictly controlled.
Thus it has been suggested that these two genes have a key role in the regulation of the uptake of magnesium and other cations in the intestine [ 24].
With regard to Mg administration it is further important not to feed roughage from pastures over-fertilised with potassium, as a high [K+] decreases the uptake of magnesium [ 4].
A regular newsletter will be sent to all hospitals for distribution to relevant local health professionals highlighting overall progress in the project, and giving information on the latest rates of uptake of magnesium sulphate for neuroprotection from those sites participating in the 'WISH audit of uptake and health outcomes data collection'.
Dietary calcium and magnesium may affect the intestinal uptake of each other, though results are conflicting, and likewise the role of vitamin D on intestinal magnesium absorption is somewhat uncertain.
