Sentence examples for magnesium block of from inspiring English sources

This is in line with the general view of glutamatergic transmission [17], which begins with a fast response generated by AMPAR [18], and the resultant membrane depolarization then leads uncoupling of magnesium block of NMDAR channels to allow calcium entry into the neurons [19], [20], suggesting the role of AMPAR activation is just a prerequisite for NMDAR activation.

Among these is coincident glutamate stimulation of NMDA receptors and local membrane depolarization sufficient to remove the magnesium block of NMDA receptor channels.

The first of these possibilities could result from a changed form of extracellular ATP (i.e. an increase in ATP4−) or from relief of the magnesium block of P2X4 receptors (Negulyaev & Markwardt, 2000).

The resulting vasodilatation reflects both the presynaptic activity and the level of postsynaptic depolarization, which changes the magnesium block of NMDA receptors and the resulting influx of calcium (Attwell and Iadecola, 2002).

ALA activates a neuronal background rectifying potassium channel [ 65] leading to membrane hyperpolarization which in turn increases the magnesium block of the calcium channel associated with NMDA receptors which play a predominant role in mediating glutamate-mediated excitotoxic neuronal cell death [ 58, 61].

Many in vitro studies support a model in which modifiable synapses detect presynaptic activity through glutamate binding to postsynaptic receptors and detect postsynaptic activity through depolarization, which relieves magnesium block of N-methyl-D-aspartate (NMDA) receptors (NMDARs) and activates voltage-gated calcium (Cav) channels.

Depolarization associated with the action potential substantially reduced the magnesium block on NMDA.

Hold the block of magnesium tilted at an angle above your tinder pile, then use a knife or metal blade to scrape along the length of the magnesium block to create small shavings.

It is possible that glutamate binding to NMDA receptors in our system could be acting via non-ionotropic actions that do not require depolarization and relief of magnesium block (Vissel et al., 2001).

Over a range of negative membrane potentials, approximately 10% of the current through NMDA channels was carried by calcium which, in the absence of the magnesium block, has an approximately linear I-V-relationship through the range of physiological voltages [48], [49], [50], [51].

A model of ligand-gating of the L-mode of NMDA receptors [37] was modified to take into account the voltage dependence of the magnesium block.