Sentence examples for magnesium binding site from inspiring English sources

2) Localization of the functional magnesium binding site of the DBP should co-respond with conserved D and E residues in the DBP as well as corresponding regions of the RAG-1 protein.

In this alignment the hypothetical positions of a magnesium binding site and site of double stranded DNA binding in the ICP-8 protein are shown, potentially orienting a bound magnesium ion towards the bound DNA strand to permit, for example, magnesium dependent strand exchange typical of DBP proteins such as ICP-8.

This action substantially perturbs the magnesium binding site, which is primarily formed by T92.

To test this we used a nuclease-dead version of Pacman, where the critical glutamate in the conserved magnesium binding site has been mutated to a glycine (E177G).

On the other hand, there are relatively few crystallographically characterised magnesium binding sites [15].

For comparative purposes, it would be helpful if the complete crystal structure of both RAG and DBP proteins were solved so that, for example the location of the respective DNA binding sites and magnesium binding sites could be compared.

Therefore, these magnesium binding sites and mode of magnesium release may not be universal for all kinases but likely control many kinases.

Its main features involve: (i) a clear magnesium-binding site; (ii) an alpha-helical conformation for the so-called LID region; and (iii) a high density of positive charges in the active site.

It is known that lithium at therapeutic concentrations inhibits GSK-3β activity directly, by competition with the enzyme for a magnesium-binding site, and indirectly, by phosphorylation of serine-9 in the pseudosubstrate domain of the enzyme through the activation of Akt [32].

This regulatory element consists of a magnesium-binding site (Asp-Phe-Gly (DFG) motif), a short β-strand (β9), the activation loop and the P+1 loop.

Two zinc- and one magnesium-binding sites are found in each DraIII monomer (Fig. 3A).