Sentence examples for magnesium binding loop from inspiring English sources

Conserved secondary elements in this segment include the magnesium binding loop, β9, at the N-terminus, the centrally located activation loop (A-loop) and the P+1 loop at the C-terminus.

These regions are summarized in Fig.  6, and include the catalytic loop, magnesium binding loop and the F-helix region.

A significant reduction in fluctuations is seen with all tested ligand types at the first nine residues of the activation loop which includes the "magnesium binding loop" (residues 200−205).

Sequence signatures reflect substrate specificity within the APH family: Our mcBPPS analysis revealed that the magnesium binding loop in subdomain VII of APH2 is characterized by an APH2-specific aspartate (D) right after the DFG motif (DFGD).

For example, mutation of the glutamate within the magnesium binding loop (DFE-Glu, E332) to an aspartate reduces k cat by half and increases Km for choline 3 fold.

A model of Kdo based on a Rio kinase structure (Additional file 4: Figure S4) suggests that the magnesium binding loop lysine (subdomain VII) and the two arginines in the F-helix (subdomain IX) are juxtaposed for hydrogen bonding with the substrate.

As for the MTRK and Choline kinases, group-specific residues are found in the F-helix, and the magnesium binding and catalytic loops (Fig.  6).

Many studies of Ras superfamily GTPases use a serine to asparagine (S22N) mutation in the P-loop since this prevents magnesium binding, and hence stable GDP or GTP binding.

Rho GTPases have well-defined nucleotide and magnesium binding pocket, constituted mainly by two polypeptides called Switch I and II and by the phosphate-binding loop or P-loop.

On the other hand, there are relatively few crystallographically characterised magnesium binding sites [15].

Such discussions are hindered by the lack of reports of the magnesium binding affinities to these substrates.