"We knew so little about the nervous system, we had little idea about how to make these therapeutics.
For example, Cohen warns that peptides "do not make great therapeutics," because of how easy they are to break down in the body and their potential for causing immune reactions.
To make novel therapeutics, targeting lipid metabolism has been considered as a potential and alternative strategy to combat obesity.
The role of αvβ3 integrins in angiogenesis may make such therapeutics especially useful for the treatment of rheumatoid arthritis and metastatic bone disease.
One of the fundamental advantages of multicomponent therapeutics is the production of "synergy", that is, the combinational effect to be greater than the sum of the individual effects, making multicomponent therapeutics a systematic approach, rather than the reductionism of an additive effect.
While great advancements have been made in HIV/AIDS therapeutics, there is still no cure or viable vaccine in development.
Moderna's mRNA therapeutics, made with proprietary nucleotide analogs, have the potential to generate any conceivable protein using the body's own cellular machinery.
They were seen as pivotal to the FDA's 2016 decision to grant approval for the drug, made by Sarepta Therapeutics.
Syndros is made by Insys Therapeutics, an Arizona-based pharma company accused of using dubious marketing practices to sell Subsys, a spray form of the powerful synthetic opioid fentanyl approved by the FDA to treat cancer pain.
Progress on technologies in the identification of PPI modulators and the clinical validation of the PPI pairs has made anti-cancer therapeutics by interfering with PPIs a reality [ 16, 19].
While significant progress has been made in therapeutic antibodies, perhaps the most rapid advances have been made in nonantibody therapeutics, including the development of small-molecule inhibitors that modulate key pathways important in NHL pathogenesis.
