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The study identifies particular mutations that made the virus spread so easily.
The other mutation, he said, known as A193T on the H gene, made the virus better at infecting people.
In the end, the company Cell Genesys made the virus, and Dr. Aubourg treated two boys from Spain.
She made a point mutation in the SOX gene that, in cultured cells, made the virus ineffective at blocking host gene expression.
Fouchier was unable to confirm the specific mutations that made the virus more transmissible, but said many had already been spotted in the wild.
Instead, they found that inserting a particular mouse gene made the virus deadly for breeds of laboratory mice normally resistant to the disease.
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But what mutations would make the virus more easily transmissible?
Fouchier hoped to characterize the properties that make the virus so much deadlier than others.
But a mutation making the virus more transmissible could set the stage for a pandemic.
Several features of rabies infection make the virus particularly useful for this purpose.
The mutation slightly changed the shape of the spike, making the virus more transmissible.
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