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The replicating chains were caught in oily bubbles, which protected them and made replication easier; eventually, they began to venture out into the open sea.
The recommendation is to check for interaction with other polymorphisms (see, for example the replicability of 'novelty seeking', where interaction of at least three gene loci made replication uncertain [ 122].
Investigators have detected significant genetic markers from relatively modest sample sets based on quantitative traits (e.g., (Hu et al. 2011b)) yet the additional requirements in characterizing phenotypes (e.g., longitudinal quantitative traits) have also made replication studies more challenging.
However, we made replication of the original search from 2011 to September 2013 in order to check if any new PSDs will occur in comparison with the initial search and the results did not identify new PSDs.
Stringent QC procedures might not be enough to distinguish real signal from noise, which made replication with qPCR a necessary step to validate the presence of these apparent mutations.
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"Video makes replication more efficient," Pritsker said.
Mr. Steeg said a one-and-a-half-inch hologram had been set on every Super Bowl ticket, making replication virtually impossible.
We even went as far as to create a public webpage where anybody can review and rate the same abstracts as we did to make replication as easy as possible.
In March Dr Nosek unveiled the Centre for Open Science, a new independent laboratory, endowed with $5.3m from the Arnold Foundation, which aims to make replication respectable.
Often, only people with an axe to grind pursue replications with vigour a state of affairs which makes people wary of having their work replicated.There are ways, too, to make replication difficult.
Too often, rules are so vague and complex as to make replication impossible".Fibonacci numbers at least have the virtue of creating a testable proposition; one that they appear to fail.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com