Sentence examples for made of hyperphosphorylated from inspiring English sources
In Alzheimer's disease (AD), these inclusions are made of hyperphosphorylated tau protein.
By immunohistochemistry, deposits made of hyperphosphorylated tau protein were present in neurons, astrocytes and oligodendrocytes in all affected brain regions.
Filaments made of hyperphosphorylated tau protein are a good predictor of the cognitive state in Alzheimer's disease, because a negative correlation has been described between the number of neurofibrillary tangles, and the Mini-Mental score (Giannakopoulos et al., 2003).
Alzheimer's disease (AD) is the most common form of dementia and is characterized by the accumulation of amyloid- β peptide (A β) and the formation of neurofibrillary tangles made of hyperphosphorylated tau (h-tau).
At the age of analysis (12 months), brains of heterozygous P301S mice develop neuronal inclusions made of hyperphosphorylated (AT8 positive, pretangles) and aggregated tau (AT100- and Gallyas silver-positive, classical tangles).
The pathological hallmarks of AD are neuritic plaques mainly composed of the β-amyloid (A β) peptide as well as intraneuronal neurofibrillary tangles (NFT) made of aggregated hyperphosphorylated microtubule-associated protein (MAP) tau (h-tau).
The former are composed of intraneuronal aggregates of hyperphosphorylated tau proteins and the latter are made of amyloid-beta (A β) peptides stemming from the sequential cleavage of a transmembrane precursor named amyloid precursor protein (APP).
Filamentous inclusions made of the microtubule-associated protein tau in a hyperphosphorylated state are a defining feature of a large number of human neurodegenerative diseases.
In AD brain tau protein accumulates in the form of hyperphosphorylated form.
Indeed, brains from suspected CTE cases that have come to autopsy have been confirmed to have deposits of hyperphosphorylated tau in locations that make its anatomical distribution distinct for other tauopathies.
Alzheimer's disease is characterized by amyloid plaques (neuritic or dense-core), composed of amyloid-beta peptides (Aβ) and neurofibrillary tangles made up of paired helical filaments of hyperphosphorylated tau protein (pTau).
