Of particular interest was a vaccine made of attenuated P. falciparum sporozoites (PfSPZ).
In conclusion, numerous efforts have been made to attenuate the expression of argF, at both the translation and transcription levels, with the aim to increase the production of l-ornithine.
Attempts have been made to attenuate HMGB1-mediated effects in experimental sepsis, including anti-HMGB1-antibodies [ 4], HMGB1 antagonists [ 10] and neuropeptides [ 11].
Given the clinical relevance of this disease, significant efforts have been made to attenuate consequences of tissue ischaemia by stimulating angiogenesis the growth of new blood vessels from pre-existing ones.
Much effort has been made to attenuate the microcirculatory disturbances by ablating a single factor in the pathogenesis, including introduction of recombinant tissue plasminogen activator (rtPA) 4, 5, antioxidants, anti-intercellular adhesion molecule-1 (ICAM-1) antibody, calcium-stabilizing agents and anti-excitotoxic agents.
Dipolar evolution is not refocused during a rotor cycle of the S1 acquisition, and the pair makes an attenuated contribution to the S1 signal.
The nasal vaccine, called FluMist, is made of an attenuated live virus.
The Sabin vaccine, though easier to use and highly effective, was made from live attenuated viruses, some of which apparently retained their infectious potential.
The dengue vaccine, which is made of live, attenuated viruses, is one of the most important products in Sanofi's pipeline, with some analysts expecting sales to exceed $1 billion a year.
Unlike conventional vaccines made from live attenuated pathogens or killed organisms, such a vaccine would carry no risk of infection.
Moreover, administering this vaccine can be seen by parents as the closest thing to a natural infection, since it is made of live attenuated viruses of its three target diseases [ 62].
