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"made a significant difference" is a grammatically correct and commonly used phrase in written English.
It can be used to describe a situation or event where something has had a major impact or effect. Example: The new team member's innovative ideas and hard work made a significant difference in the company's productivity and sales.
Exact(59)
Ripken has made a significant difference in major league baseball.
The age of the mother made a significant difference.
Sisay says improvements in HIV diagnostics have made a significant difference, particularly for monitoring pregnant women.
However, the few that have put healthy eating on the agenda have made a significant difference.
Organisers say the singer's bravery in speaking out has made a significant difference.
In particular, the type of water used made a significant difference.
It made a significant difference to the Mirror's headline figure of course.
"Everyone knows that Setanta has made a significant difference to the money available to the FA.
Lowe Lintas' New York campaign, he added, "has really made a significant difference in the last year".
So far, there's no evidence that Comey or any other October or November surprises made a significant difference.
This has made a significant difference in the short term but, more importantly, laid the foundations for a brighter future.
More suggestions(15)
made a remarkable difference
made a substantial difference
made a vast difference
made a tangible difference
made a noticeable difference
achieve a significant difference
made a significance difference
made a salient difference
made a major difference
made a considerable difference
made a sizeable difference
makes a significant difference
tested a significant difference
made a notable difference
exert a significant difference
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com