ScienceNow quotes Harvard's Martin Nowak as saying the study "tells us nothing about whether Hamilton's rule makes a correct prediction for actual biological systems". (Nowak, a biologist, has a horse in this race: he has written in opposition to Hamilton's rule).
"[The work] tells us nothing about whether Hamilton's rule makes a correct prediction for actual biological systems," he says.
On average, in the scenario when the 'top 1' ranked prediction of DTIs are considered in LOOCV, DASPfind makes a correct prediction in 46.17 % of cases across the four gold standard datasets and in 40.13 % across all six datasets we used.
This is because if one gene is in 100 GO categories (high multifunctionality), and another is in only one (low multifunctionality), by placing the former gene ahead of the latter gene in a fixed ranking, we make a correct prediction more often across all GO categories.
Therefore, it is easier to make a correct prediction on non-hub proteins than hub proteins.
Knowledge of these Pavlovian contingencies was demonstrated by making a correct prediction in the last two presentations of each stimulus (where the chance level is 1/32; Six participants were excluded for inaccurate Pavlovian knowledge).
The accuracy measure employed for evaluating the results is the percentage of instances correctly classified, that is, for which a correct prediction was made.
The proportion of subjects for which a correct prediction is made is an estimator of the prediction accuracy.
He also made the correct prediction that the states of Michigan, Pennsylvania, Wisconsin and Ohio would be key and could become what he termed "Brexit states".
But actually, Malink argues, Aristotle's theory made the correct prediction.
Using these yeast phenotypes, we have previously made correct predictions of a gene-dosage-related phenotype for their orthologous human genes [ 9], and verified these predictions by controlled RNAi knockdown in human cell lines [ 10].
