These findings suggest that our approach facilitates creating functional macroscopic tissue used in various fields such as drug screening, wound healing, and plastic surgery.
The resulting macroscopic tissue changes in human cartilage disks were similar (elliptical appearance) to those described previously using our human cartilage injury model and scoring system [ 36].
Further culturing resulted in three-dimensional (3-D) growth, which ultimately produced macroscopic tissue 2 mm in size within 4 weeks.
There are a variety of neurotrophic factors that have been identified and studied at various levels from molecular interactions to macroscopic tissue responses (reviewed in [ 3– 6]).
Macroscopic tissue fragments were fixed in 4% formaldehyde and embedded in paraffin.
The expression of the reporter gene reflects, at the macroscopic tissue level, at least in some diagnostic situations, the expression of the therapeutic gene [ 44].
A 20% ADC increase resulted in clear macroscopic tissue damage.
Most importantly, macroscopic tissue necrosis or cyst-like properties were not observed in the orthotopic model tumors.
Macroscopic tissue fragments were too small to fortify cryostat sections and were therefore embedded in formalin and fixed in paraffin disabling G6PD viability staining.
The decreases in FA along with increases in MD were attributed to the reduced microstructural integrity with macroscopic tissue loss or interstitial edema.
