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The average macroscopic score was expressed as a cumulative value for all paws, with a maximum possible score of 16.
The average of the macroscopic score was expressed as a cumulative value of all paws, with a maximum possible score of 12. Mast cells in synovium were visually assessed for intact versus degranulating mast cells using morphologic criteria.
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This macroscopic score is the result of the assessment during necropsy and tissue trimming.
The mean macroscopic scores were 5.8 points at 4 weeks and 5.9 points at 12 weeks.
Nonparametric data (macroscopic scoring) were analyzed using Kruskal-Wallis test (nonparametric ANOVA) followed by a Dunn's multiple comparisons post test.
When the individual parameters of the different macroscopic scores were correlated, the parameters "defect fill" and "total points" reflected well the data from the two-dimensional (2D) MOCART score assessment.
The macroscopic OA score was significantly lower in the HA + MSC group than in the other groups.
In all animals, the macroscopic osteoarthritis score was better in the BMP-7 injected knee than in the contralateral control knee.
Macroscopic colitis score was calculated according to the criteria shown in Table 2. Animals were anesthetized by isoflurane and exsanguinated via the carotid artery.
This matched pair analyses demonstrated that both macroscopic and microscopic scores were better in the BMP-7 injected knees than in the contralateral control knees in all rabbits at 12 weeks.
Colon length from cecum to anus, weight, and a macroscopic colonic damage score were recorded The macroscopic colonic damage score was based on the degree of tissue adhesion, mucosal ulceration, and intestinal wall thickness (Table 1) [ 37].
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