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However, liver resection should have the potential for complete macroscopic resection in curative intent [ 21].
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Complete macroscopic resection was performed in 65 of the 70 patients (93%) who received capecitabine CRT.
Complete macroscopic resection was achieved in 71.4% (110 of 154) of the patients.
Surgical approach in patients with colon cancer consisted of standard hemicolectomy (via laparotomic or laparoscopic approach) with negative macroscopic resection margin and regional lymphadenectomy in all cases.
In our study, 93% of the patients who received capecitabine CRT went on to have a complete macroscopic resection, although there is some variation in the timing of surgery.
c Macroscopic resection specimen.
Patients with limited metastatic disease (distant intra-abdominal lymph nodes and/or a maximum of one organ involved in metastatic disease, ECOG-PS < 1) received eight cycles and underwent surgical resection when a complete macroscopic resection seemed possible.
This is the first study that tests the relevance of cetuximab in addition to a triplet combination as first-line treatment for metastatic colorectal cancer and uses the rate of macroscopic resection of liver metastases as main end point.
Interestingly, in recent meta-analysis of three randomised trials the rate of complete macroscopic resections of liver metastases was 12.5% in men using chronomodulated delivery vs 7.8 8.5% in men using conventional delivery, or in women on either schedule (Levi et al, 2009).
In total, 28 of 31 (90%) patients underwent surgical resection and 27 of 31 (87%) had complete macroscopic resections.
Four months after the third course of I-MIBG therapy, she underwent a (macroscopic complete) surgical resection in the home country, despite the presence of surgical risk factors.
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