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Such macroscopic changes are not immediately reversed when the size of the field is reduced or when its direction is changed.
These macroscopic changes are supported on the molecular level by increased postsynaptic density-95 protein in the amygdala, consistent with stress-induced plastic changes and synaptic strengthening.
Three important experimental design elements enhanced the clarity and relevance of our findings: 1) We used the most resistant variety of P. thunbergii, 'Namikata-73'; resistant rank 5. 2) We sampled inoculated trees (both resistant and susceptible) 1, 3, and 7 dpi before any macroscopic changes usually occur; resistant trees were also sampled 14 dpi, when macroscopic changes are usually evident.
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At higher collagen concentrations (4 and 6 mg/mL), cluster growth was stimulated and macroscopic changes were observed.
In tendon, the link between mechanical loading and microstructural damage, resulting in macroscopic changes, is not fully elucidated.
The macroscopic changes were monitored by permeability measurement and mechanical strength tests coupled with a microscopic characterization by ATR-FTIR (to identify the chemical functional groups affected by ageing) and SEM (to visualize qualitatively the surface changes and deteriorations).
No macroscopic changes were observed.
On immunohistochemical examination of the specimens, macroscopic changes were observed.
Macroscopic changes were noted, and we selected the hippocampus for microscopic examination, after paraffin embedding.
In 35 (52.24%) animals, macroscopic changes were observed in the liver.
No macroscopic changes were observed in controls or with indomethacin and nabumetone 1 hr after drug administration.
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