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This issue has already been explored recently by de Visser and colleagues [15] who found that PDE4 inhibitor therapy prolonged median survival of hyperoxia-exposed pups, reduced alveolar fibrin deposition, lung inflammation as evaluated by albumin content in BAL and macrophage count in histological studies.
In the latter study, a reduced macrophage count in obese PVAT after bariatric surgery was found.
Histological analyses and measurement of macrophage count in adipose tissue was performed as previously described [ 12].
The macrophage count in the ESCC tissue samples was conducted as described previously.
Macrophage count in PVAT was quantified after CD68 staining and presented as the fraction of the number of adipocytes.
The leptin expression and macrophage count in CAD group were significantly higher than in non-CAD group, but CAD patients had a markedly lower CTRP9 expression (P < 0.05).
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In addition, macrophage counts in the PL fluid were significantly reduced by VT treatment.
The expression level of MCP-1 correlated with macrophage counts in the interstitial space (r2 = 0.47, p = 0.002) but not in glomeruli (r2 = 0.002, p = 0.857).
The differences in macrophage counts in mice challenged with live A. fumigatus conidia were not statistically significant, with respect to naïve mice).
Other studies with Ceria reported higher macrophage counts in BALF using the same or a higher number of washes (Gosens et al. 2013; Ma et al. 2011).
Preventive administration of nintedanib once daily at 30 and 100 mg·kg−1 by gavage reduced neutrophils and lymphocytes, but had no effect on macrophage counts in the BALF.
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