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In this cohort, a Cox regression analysis adjusted by severity identified that macrolide use was associated with lower ICU mortality (HR, 0.48; 95% CI, 0.23-0.97; p = 0.04) compared with the use of fluoroquinolones.
This finding may explain the link between macrolide use and decreased mucus secretion in a variety of chronic airway diseases [37].
The model and results presented here are specific to the introduction of ketolides into a population exposed to high rates of penicillin and macrolide use.
Relative proportions of macrolide use were lowest in Denmark.
Proportions of macrolide use increased with age (Table 2).
Community macrolide resistance has increased following increased macrolide use.
Macrolide use was chronic and not new in any patients.
The figure shows the rate ratios of IHPS according to macrolide use.
An overall 30% macrolide use is seen in the present study.
Data on macrolide use in obese patients with pneumonia are scarce.
Decreased macrolide use has led to a decrease in macrolide-resistant pneumococci.
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