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TLA was obtained with the Optimass© software thanks to a macro written by P. Belluomo (INRA Grignon).
The fibril spots containing the highest protein amount (500 ng) were analyzed by densitometry using Gilles Carpentier's Dot-Blot-Analyzer macro (written by Gilles Carpentier, 2008.
ICC was calculated using the %INTRACC macro written by R.M. Hamer (http://www.psych.yorku.ca/lab/sas/intracc.htm).
We used the SAS macro written by Fox et al (2005b), which was adapted to perform conditional logistic regression.
A modification of the stratified Cox proportional hazards model was used to compute risk estimates using a macro written by Langholz and Jiao [ 8] that computes standard errors using an asymptotic variance estimator appropriate for the analysis of case-cohort designs.
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We used the SAS-macro written by Fox, Lash and Greenland, which was adapted to perform conditional logistic regression (Fox et al, 2005b).
RECPAM analysis was carried out with a macro written in SAS by one of the authors (F.P .. Baseline clinical features of the 679 study patients are shown in Table 1.
Tubular structures were observed after 8 h of cell incubation at 37 °C and five randomly chosen fields of each well were acquired using an Axiovert 200 microscope (Carl Zeiss, Germany) and processed by Angiogenesis Analyzer macro written for ImageJ software (http://image.bio.methods.free.fr/ImageJ/ Angiogenesis-Analyzer-for-ImageJ.htm).fr/ImageJ/ Angiogenesis-Analyzer-for-ImageJ.htm
Trials were recorded by using a CCD camera and were analyzed by using the public domain NIH Image program (rsb.info.nih.gov/nih-image), using a macro written specifically for the Barnes maze [27].
The macro BETABIN written by Ian Wakeling [ 12] is freely available.
Analysis of chromosome condensation patterns were performed by the CHIAS IV system using the macro programs written by Seiji Kato, Nobuko Ohmido, and Kiichi Fukui.
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