Exact(12)
Posavec, M., Timinszky, G. & Buschbeck, M. Macro domains as metabolite sensors on chromatin.
In developing countries, there exists the Multidimensional Poverty Index (MPI), [40] which is calculated as a weighted mean of three macro domains (i.e., health, education, and standard of living) at household level.
In vertebrates, macro domains are frequently found in tandem with modules involved in ADP ribosylation or the polymerization of poly(ADP-ribose) (PAR) as well as ATP-dependent chromatin remodeling [15], [17].
Macro domains have been shown to bind to poly(ADP-ribose) (PAR) [ 72].
Interestingly, the only conserved domains we found were macro domains, which we discovered in 20 putative Inc proteins.
Macro domains could also represent attractive and novel drug targets, likely in connection to the well-established SIRT1 pathway.
Similar(48)
Karras, G. I. et al. The macro domain is an ADP-ribose binding module.
These PARPs contain the Macro domain and/or the WWE domain both of which are PAR-binding modules5,6,16,24.
'De-coupled' CFD method was employed based on previously author's published work by simulating the effect of external environment (macro domain) onto RPSC system (micro domain) in two separate CFD modelling.
The slightly higher binding affinity of ADP-ribose toward the nsP3 macro domain of VEEV, as predicted by the simulation results, is in good agreement with previous experimental data.
At present, no drug or vaccine is available for the treatment and therapy of both viral infections, but the non-structural protein, nsP3, is a potential target for the design of potent inhibitors that fit at the adenosine-binding site of its macro domain.
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