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The single-particle approach to cryo-EM, which emerged in the late 1970s (Frank et al., 1978; van Heel and Frank, 1981), offered the possibility of being able to determine the atomic structures of cellular machinery without the need for crystals, as required for X-ray crystallography.
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This makes it possible for a chemical outside the cell, such as a molecule of an odorant, to communicate with and produce changes in the cellular machinery without entering the cell.
This makes it possible for a chemical outside the cell, such as a molecule of an odorant or a tastant compound, to communicate with and produce changes in the cellular machinery without entering the cell.
In summary, M-CTX-Fc was shown to inhibit and arrest the cell proliferation machinery without being toxic to the cells.
The company's biggest concern is that people would use the machinery without trained supervision.
Her presentation amounted to an indictment of Lender Processing Services, or LPS, a company near the center of ongoing state investigations into claims that foreclosures have been rushed en masse through the legal machinery, without proper documentation.
XPA is a critical component of the NER machinery, without which repair activity ceases.
As controls, we also generated tumor cells that expressed a scrambled shRNA sequence that activates the RNAi machinery without inducing knock-down of NRF2.
An alternative miRNA biogenesis pathway, called miRtron pathway, has been discovered among diverse mammals, drosophila and nematodes (Berezikov et al, 2007; Okamura et al, 2007; Ruby et al, 2007): miRtrons are regulatory RNAs, which get processed to form pre-miRs using the splicing machinery without Drosha-mediated cleavage.
There can be no real progress in overhauling America's voting machinery without bearing in mind three fundamental principles.The first is the basic importance of the federal idea.
Indeed, I'm going to go out on a limb here and say that the idea of remotely operating heavy machinery without special training is, categorically, a bad idea.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com