Although there has been much recent progress in understanding the general polarizing machinery of epithelia, it is largely unclear how this machinery is controlled by the extracellular environment.
The last few years have witnessed tremendous growth in understanding both the extrinsic and intrinsic cues that position the mitotic spindle, the varied mechanisms in which the spindle orientation machinery is controlled in diverse organisms and organ systems, and the manner in which the division axis influences the signaling pathways that direct cell fate choices.
I think there will always be an aspect of controlling a piece of machinery, of two or three thousand pounds of machinery being controlled by very minute movements of your hand… Taking yourself to the limit, taking the machine to the limit; there's something in our brain wired to enjoy that, so hopefully that's always a part of it.
We describe that, indeed, the neuronal ER is a dynamic organelle and that the fission machinery is controlled specifically by NMDA receptor activity.
The host cellular machinery is controlled by a highly complex, dynamic and regulated modular protein interaction network [ 15].
Although several signaling pathways regulate autophagy, signaling from the cytoplasm to the autophagy machinery is controlled in a negative manner through serine/threonine kinase, a mTOR.
It is therefore important to unravel the principles of mitochondrial fusion by identifying all the components that constitute the core fusion machinery and to understand better how this machinery is controlled and integrated into cell signaling pathways.
We conclude that voltage-gated Na+ channels are regulated by miR-375 in insulin-secreting cells, and validate that the exocytotic machinery is controlled by miR-375 also in INS-1 832/13 cells.
Cell cycle machinery is controlled by complexes of cyclin and cyclin-dependent kinases (CDKs), and one of the CDKs, CDKA 1, acts at the G1/S transition and in G2 (Francis 2007).
It has been suggested that because in the individual cell the transcriptional machinery is controlled by a relatively small number of transcription factors, it may result in stochastic behavior in gene activity.
