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Translesion synthesis (TLS) is a DNA damage tolerance process that allows the DNA replication machinery to replicate past DNA lesions such as thymine dimers or AP sites.
In the latter case, viruses need to infect the cells, manipulate the host replication machinery to replicate their genomes and get released from the infected cells without killing the host or triggering the immune system.
One major function of the early adenoviral gene products, such as E1A and E1B, is to push the infected cell into the S phase of the cell cycle (Flint and Shenk, 1997), since it is necessary for the virus in order to use the cellular DNA replication machinery to replicate its own genome efficiently.
They infect a cell, hijack its machinery to replicate themselves, and then escape to infect new cells.
The first is to find out if stem cells and cancer cells may use the same genetic machinery to replicate themselves.
Viruses are the only organisms known to store their genetic information solely in the form of RNA, and have thus evolved unique machinery to replicate an RNA genome and initiate viral gene expression in the infected cell.
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The plastid is a nearly autonomous organelle because it contains the biochemical machinery necessary to replicate and transcribe its own genome and carry out protein synthesis.
Due to the inability of the semiconservative DNA replication machinery to fully replicate DNA ends of linear chromosomes, terminal chromosomal DNA is lost with each cell division, which, in the absence of a mechanism to restore telomere length, eventually leads to critically short telomeres and cellular senescence or apoptosis.
The addition of telomeric repeats relies on the activity of the telomerase enzyme [ 138], a specialized reverse transcriptase that compensates for the erosion that results from the inability of the semiconservative DNA replication machinery to fully replicate chromosome ends [ 139, 140].
Phylogenetic analysis demonstrated a close relationship between Vigna and Phaseolus in the phaseolinae subtribe and provided a strong support for a monophyletic group of the eurosid I. Chloroplasts (cps) are plant organelles that contain biochemical machineries necessary to replicate and transcribe their own genomes.
As mammals age, their telomeres become shorter during each round DNA replication due to the inability of the transcription machinery to completely replicate the ends.
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