Sentence examples for machinery stimulation from inspiring English sources

Naked RNAs have potential toxicities such as saturation of the innate RNAi machinery, stimulation of the immune response, and off-target effects.

The effects of EGFR activation on tumour cells are multiple and convergent, thus favouring uncontrolled cell growth with an increase in cell mobility and cell proliferation, a decrease in apoptotic machinery and stimulation of angiogenesis.

Previous experiments were using smaller concentrations similar to those used for Rap Rap1GAP, which might have led to the erroneous conclusion that Tuberin does not contain the machinery for GTPase stimulation.

Although many of the components of human presequence translocase such as Tim17a, Magmas and JC15 are variably expressed in the subset of cancer cells, obtaining a direct link between dynamic restructuring of translocation machinery leading to stimulation of cellular death machinery was obscure.

If a major role of Gap1 is to detect the presence of amino acids and other potential nitrogen sources in the medium, and to activate the cellular machinery for rapid stimulation of the initiation of protein synthesis and fermentation, the substrate promiscuity of Gap1 for non-metabolizable amino acid analogs makes more sense.

CTLA-4 is an inhibitory component of the co-stimulation machinery associated with T cell receptor signalling, and may act by competing for ligand with the CD28 stimulatory receptor, and by raising the activation threshold of T cells through the immunological synapse 66.

Moreover, modifications in the Ca2+-signaling machinery coincide with autophagy stimulation.

Importantly, unlike what has been demonstrated for trypomastigotes (Schenkman et al., 1991; Martins et al., 2011) phagocytosis of T. cruzi EAs is not dependent on the parasite's ATP stores, but appears to be solely driven by the host cell phagocytic machinery after attachment and stimulation by the parasites.

In particular, mutations in CSN5 or Nedd8, the key invariable components of the CSN machinery, caused either inhibition or stimulation of dendritic elaboration.

DOI: http://dx.doi.org/10.7554/eLife.04885.016 We further tested the functionality of calcium-handling machinery in myobundles by biochemical stimulation with caffeine and acetylcholine (ACh).

Consistent with relatively poor activation of the signaling machinery observed earlier, anti-IgM-mediated stimulation also resulted in a weak perturbation of the TF network.