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The lichenicidin and haloduracin biosynthetic machinery specificity was investigated in vivo in Escherichia coli.
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It has been postulated that palmitoylation of peripheral membrane proteins occurs exclusively in the Golgi apparatus, and that the responsible machinery lacks specificity altogether, rapidly processing any available target protein.
Experimental data suggest that this proteolytic machinery has specificity to the ASYN species that it can degrade.
Another major set of players in machinery encoding specificity of membrane fusion events are the SM proteins [ 8].
Here, we investigate whether sterol composition and components of the endocytic machinery modulate specificity of KNOLLE syntaxin localization during late cytokinesis.
The tethering complexes are the components of the specificity machinery that link all of these factors together either physically, functionally or both.
Notwithstanding this, there is clearly a distinct pattern of conservation between these two components of the specificity machinery, i.e. the poorly conserved tether complexes and the more easily detectable and more highly conserved SM proteins.
In contrast, the TRC40-independent membrane integration of Cytb5 was unaffected by trypsin treatment, confirming both the resilience of the N-glycosylation machinery and the specificity of the assay (see Supplementary Figure S5A, and also [ 11, 14]).
Receiving a Pioneer Award, Macklis said, will enable him to explore some of the central questions in neuroscience, ranging from what molecular machinery directly implements the specificity of initial developmental "wiring" of the brain to why that wiring cannot naturally regenerate.
The L. pneumophila Lens tolC::kan mutant was sensitive to a variety of compounds including antibiotics and detergents, which supports the involvement of the TolC protein in a functional MDR machinery with wide substrate specificity.
Use specific machinery.
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