The premise is that the cis-acting polymorphism that is located in close proximity to the gene is likely to affect the regulatory machinery of that same gene and that machinery is unlikely to be shared by genes other than the ones that are immediately adjacent.
Here we report that disruption of the ATPase dVps4, the most downstream component of the ESCRT machinery, causes the same array of cellular phenotypes.
In order to evaluate the activation of the DDR machinery in the same set of samples, we investigated the immunostaining for pS1981_ATM, the activated form of a key upstream regulator that controls most DDR events; the staining for pT68_Chk2, a central mediator of DDR that resulted barely detectable in IGCNU and in primary tumours was also analysed.
Because you wanted to create robots who are compliant, who keep the machinery working, the same sort of knowledge production, [but now you have] people challenging what you taught them, no interest in reproducing and want to dismantle it entirely.
Together with the CCDC6 protein, we also assessed the engagement of the DDR machinery in the same tumours and in their normal counterparts, when available.
These ASEs are also under the control of the same splicing machinery within the same cell environment in which they are expressed.
They include arguments that women have orgasms because their reproductive machinery has the same origins as those of men, who need to have orgasms to ejaculate sperm.
But it kind of dictates what you can do – you don't get into its machinery in the same way you do on a PC.
The first behaviour leads to reduced evaporative water loss at the cost of inefficient exploitation of organic energy; gaping is more compatible with optimal functioning of the metabolic machinery, but at the same time valve movements push water out of the mantle cavity, increasing levels of water loss and the risk of desiccation [ 33, 34].
Instructors each have a set of the same machinery and tools, and the studio is equipped with a woodworker's bench, two variable speed sharpening stations, a 20-inch band saw and a floor-standing drill press.
