Scientists are faced with government shutdowns, such as the US-based shutdown in late 2013 that had a major impact on researchers, disrupting grant application machinery and functionality of PubMed, a resource used by virtually every biomedical scientist in the world.
This structural family of enzymes, classed as C14, collectively exhibits a variety of substrate specificities, activation mechanisms, potential autoinhibitory machinery and N-terminal functionality.
The reviewer however is right that a more comprehensive analysis of molecular machinery responsible for key functionalities of this compartment will help understand the role that horizontal gene transfer and molecular recruitment may have in shaping cellular structure.
However, EAS of the latest marine automation systems requires the integrated functionality for both machinery and cargo monitoring.
In particular, nutrient limitation increases mtDNA/nDNA-encoded OxPHOS complexes ratio, which represents an early response that ultimately leads to OxPHOS machinery reorganization and enhanced mitochondrial functionality.
Changes in the functionality of epigenetic machinery in addition to exposure of the genome to environmental factors might therefore also contribute to increasing epigenetic diversity with age (Fraga & Esteller, 2007).
Functionality of immunosuppression-implicated machinery may be also modulated by differential nutritional and bioenergetic MDSC behaviors.
DOI: http://dx.doi.org/10.7554/eLife.04885.016 We further tested the functionality of calcium-handling machinery in myobundles by biochemical stimulation with caffeine and acetylcholine (ACh).
Therefore, to test the functionality of the death machinery, cytochrome c was added to S-100 extracts from p65 null or reconstituted cells and caspase activation was assessed.
Here, we describe the machinery by which they achieve this functionality and a method by which it may be selectively altered to enhance apoptosis and resolution of inflammation.
