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Viruses make use of the host cell's machinery for replication and are thus intracellular pathogens.
But these cells have no nucleus or DNA or machinery for copying DNA, so it can't be a DNA virus because they rely on that machinery for replication.
"The spherules cloister the viral RNA, along with its copying machinery for replication, away from processes in the host cell that might otherwise degrade it," says Ahlquist.
Since viruses utilize cellular processes and machinery for replication, understanding the mechanisms by which viruses parasitize the cell will both increase our understanding of these pathways and aid in the design of effective anti-viral countermeasures.
This is in line with the inability of BFA to inhibit FCV replication [24], as it does several picornaviruses, and further supports the notion that caliciviruses utilize a different architecture of cellular machinery for replication than do picornaviruses.
It is generally assumed that DNA viruses evolve at a similar rate to that of their hosts due to viral dependence on the host's cellular machinery for replication [44], [45].
Similar(53)
Both of these rrn operons are oriented away from the origins, presumably to avoid collisions between the machineries for replication and rRNA transcription.
As such, the HSV1 replication cycle spans the whole cell and often takes advantage of available cellular machineries for replication.
At least some insects have the cellular machinery required for replication of positive strand RNA viruses (Scotti et al. 1983; Ball and Johnson 1998; Dasgupta et al. 2003; Aliota and Kramer 2012).
The advantage of sharing the same machinery for the replication of both genetic and epigenetic information is obvious since it allows effective coupling of DNA replication and epigenetic inheritance.
It is necessary, therefore, to understand cellular processes within the context of intranuclear microenvironments that mediate the focal assembly of the machinery for transcription, replication and repair and which facilitate the orchestration of these essential processes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com