Sentence examples for machinery failed from inspiring English sources

However, on many occasions we, being 17-year-old schoolboys, were reduced to sniggers, as the much-vaunted stage machinery failed to operate correctly.

His dredging machinery failed to retrieve any concealed manuscripts.

Moreover, from the enhanced SRY expression in blood, it is logical to construe that transcriptional machinery failed to discriminate between normal and altered versions of a duplicated gene.

In the presence of abundant mRNA transcripts, it is logical to construe that transcriptional machinery failed to discriminate between normal and altered versions of a duplicated gene.

Using the simple RNAi system (of Table 1), as the transcription/translation machinery failed to show any significant changes in the system behavior.

When the chaperone machinery fails, the damaged proteins need to be eliminated and are sent for proteasomal degradation.

If the DNA repair machinery fails, activated p53 can drive the cell to apoptosis (Vousden, 2000).

Moreover, in the absence of p53, the ATR-ATM checkpoint machinery fails to recognize DNA damage, causing cells to enter mitotic phase with a high load of genomic defects.

Programmed necrosis is an alternative, molecularly distinct mode of programmed cell death that is elicited by TRAIL under conditions when the classical apoptosis machinery fails or is actively inhibited.

We reasoned that after the nuclear transport machinery fails during apoptosis, ubiquitinated Survivin molecules in the nucleus are prevented from diffusing out due to their increased effective molecular weight >40 kDa.

While caspase-dependent apoptosis is the major pathway leading to PCD, programmed necrosis can act as a backup system when the apoptotic machinery fails or is inactivated (e.g. by mutations in apoptosis-resistant cancer cells) [ 5, 28].