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This inhibition is thought to be mediated by the saturation of the cellular RNAi machinery at different levels (i.e., cleavage of pri-miRNAs by Drosha, export of pre-miRNAs by Exportin-5, processing by Dicer, and loading into RISC).
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Likewise, the basal splicing factor U2AF65 can influence the functionality of the 3′end processing machinery by assembling at different polyadenylation-associated RNA elements, including the USE.
There is also evidence that the elongation machinery is deployed in different ways at different yeast genes [ 26,53 ], and this is clearly deployed as a major point of regulation in higher eukaryotes [ 80 84].
As separate cytoplasmic and organellar translation machinery gene co-expression clusters, occurring at different time points in the Pf IDC, are observed (Table 1), it has been possible, in the present study, to make a comparison of the putative regulatory motifs in the upstream regions of these 2 sets of genes.
Figure 1 An overview of effects of Cd exposure to plants at different levels in photosynthetic machinery.
Here, we propose a directory of TAPs implicated at different levels of Plasmodium transcriptional machinery.
Do K63-linked ubiquitination and SUMOylation employ the same regulatory machinery for Akt trafficking even though modifications occur at different sites?
With the accumulation of increasing omics data, a key goal of systems biology is to construct networks at different cellular levels to investigate cellular machinery of the cell.
CK2 appears to play a central role in the regulation of gene expression and protein synthesis/degradation by acting at different levels on the complex apoptotic machinery.
This DNA, called transposons, can jump around the genome and insert themselves at different locales; at times they jam transcription machinery and cause disease.
Early teeth and the forerunners of bony skin plates appear to be the product of the same genetic machinery, regulating epithelial/mesenchyme interactions and able to produce similar structures at different locations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com