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To find out how aging and diet affects cellular machinery and functions, geneticist Tomas Prolla, aging researcher Richard Weindruch, and their colleagues at the University of Wisconsin, Madison, took muscle samples from 5-month-old mice (young adults) and 30-month old mice, which are near the end of their natural life-span.
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Analysis of SAFB1 crosslink regions and RNA targets confirms previous reports regarding its interaction with other RNA processing machinery and function.
Scientists typically don't classify viruses as living organisms, but giant viruses like these, with their own protein-making machinery and other functions normally carried out in living cells, blur the lines between what's alive and what isn't.
From these data emerges the strong link between the sperm signalling machinery and their function, emphasized by the study of metabolic architecture concretely depicted by the networks model.
The data presented above show that RAS mutant cells are preferentially sensitive to inhibition of both the DNA replication machinery and proteasome function relative to cells lacking this activated oncogene, and that this sensitization has a fundamentally different basis for the two classes of drugs.
The exosome-complex exonuclease rrp40 forms part of the exosome, which is important to the RNA-processing machinery of eukaryotes and functions in RNA degradation in both the nucleus and the cytoplasm [ 72].
The presence on AdcA of putative interaction sites with clathrin and ESCRT components raises the question of how members of the endocytic machineries interact and function with AdcA.
The training and the performance of operators, the design of the product, the condition of the tools and machinery, and factors other functions control come into play.
Importin α proteins are essential parts of the nuclear import machinery and have housekeeping functions [ 49].
Overall, in the resting stage, CCT- β probably interacts with molecules that have a role in assisting protein assembly, eliminating misfolded proteins via the UPS or ERAD machinery and governing ER functions.
Here we revealed that DBC1 could serve as a part of DNA repair machinery, and this novel function of DSB repair by DBC1 depends on its HR ability because DBC1 can generally compete with SIRT1.
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