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RLFs, which form the core of the initiation machinery, act as relay stations coupling growth regulatory and DNA damage response pathways to chromosomal replication.
While existing models depict the polarization of myosin as downstream of PCP signaling, we instead present evidence for a more complex series of interactions in which the core PCP components and the myosin machinery act in a reciprocal fashion to promote cell polarization.
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Emerging evidence indicates that DNA repair/signaling machinery acts in an integrated fashion with chromatin structure at damaged sites.
Therefore, the DNA repair machinery acts as an intrinsic cellular defense.
Thank you for sending your work entitled "Arf1/COPI Machinery Acts Directly on Lipid Droplet Surfaces to Enable Lipid Droplet Protein Targeting" for consideration at eLife.
It is therefore possible that dimer resolution does not occur until an as-yet unidentified chromosome segregation machinery acts later in the cell cycle.
This difference may reflect a delay between when small RNAs are produced, the process of aberrant RNA recognition, and when silencing machinery acts on transcripts.
It is still unclear whether the cell cycle machinery acts largely independently in regulating meristem organization, or acts by receiving the signals from meristematic pattern genes via unknown mechanisms.
Likewise, there appear to be multiple routes back to the Golgi from endosomes, but how many routes, what machinery acts for which, and where they arrive at the Golgi are not yet resolved.
Our findings uncover a function for Arf1/COPI proteins at LDs and suggest a model in which Arf1/COPI machinery acts to control ER-LD connections for localization of key enzymes of TG storage and catabolism.
We next asked whether alterations in core protein levels at junctions reflect a change in the total cellular amount of protein or whether the ubiquitylation machinery acts specifically on a junctional population.
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