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The unchanged intracellular Ca2+ decay coincides with the normal TR50 and TR90 in APP/PS1 mouse cardiomyocytes, which is also supported by the normal protein levels of SERCA2a and NCX, the main machineries to remove Ca2+ from cytosolic space for cardiac relaxation to occur, in APP/PS1 myocardium.
As a result, eukaryotic genomes are abundant in 'intrinsically insoluble proteins' and, to cope with them, eukaryotic cells have developed many complex machineries to remove them, which include the ubiquitin proteasome pathway (UPP) and the autophagosome lysosome pathway (ALP).
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SERCA is considered as the single most important machinery to remove Ca2+ from cytosolic space (responsible for 92% Ca2+ removal) for cardiac relaxation to occur [27].
For their part, farmers have been urged to reduce the risk of combine harvesters catching fire by regularly cleaning the machinery to remove chaff and dust.
"We need bulldozers or other machinery to remove all this earth and get the bodies out, or the survivors if there are any," he said.
ISTANBUL — Rescue crews dug with their bare hands, used heavy machinery to remove chunks of fallen concrete and relied on cellphone calls from the missing in the search on Monday for survivors of the deadly earthquake in eastern Turkey.
Power shovels serve as essential machinery to remove wreckage and help accessing inner parts of disaster stricken areas.
Mechanical methods include the use of chippers and other machinery to remove hazardous fuels and thereby reduce the risk of wildfire events.
Perhaps, therefore, there is no need for machinery to remove them.
UPR can also induce components of the protein degradative machinery to remove misfolded proteins, which are tagged by ubiquitin and degraded in the proteosome.
Cell cycle arrest is often considered inhibitory to the induction of cytotoxicity and is known to be important in enabling the nucleotide excision repair machinery to remove cisplatin adducts (Siddik, 2003).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com