Alterations in the epigenetic machinery that lead to uncontrolled cellular proliferation have become an important research topic in the field of oncology.
This indicated that the antitrypanosomal activity of compound 1 is, at least in part, mediated through base modifications recognized by the MMR machinery that lead to persistent DNA breaks.
Thus, alterations in the release machinery that lead to changes in the kinetics of neurotransmitter release may be connected with network hyperexcitability possibly through a change in tonic inhibition, as we propose here.
We have added a paragraph to the end of the paper to further speak to the broader significance of our findings: "More broadly, our results demonstrate that evolutionary innovations may rely not only on the acquisition of novel genes or the co-option of molecular machinery that lead to the successful colonization of new niches".
The Luddites have been mocked for attacking the productivity-enhancing machinery that led to unprecedented improvements in living standards.
But there is room for scholarly inquiry into the working of the murky state machinery that led to that outcome to determine whether the tragedy was principally the result of murderous design or culpable neglect.
The great propaganda machinery that led them into believing that this was real, that there must be some smart people knowing what they're doing, is the curse of a bull market.
Pegeen's lesbianism is above all a crucial piece of the plot machinery that leads Axler from depression at the opening of the novel to even worse depression at the end.
In summary, we here provide solid evidence that polyamines (i) are associated with mast cell secretory granules, (ii) are important for the correct maintenance of granule homeostasis (including appropriate storage of histamine) and our results (iii) suggest an important role for polyamines in regulating the complex machinery that leads to the formation of these organelles.
The cell cycle variation in their abundance, their localization within the cell, and the sensitivity of their distribution to depletion of components with known roles in generating asymmetric spindle pulling forces, provide strong evidence that the invaginations are pulled by the same force-generating machinery that leads to asymmetric spindle positioning.
