We experience ourselves at the level of thoughts, decisions, and intentions; the machinery that generates those higher-order properties is obscured.
But the stock market's persistent upward climb since the spring of 2009 has revealed another massive disparity: the multinational corporate machinery that generates stock gains has become unmoored from the economic reality in which the vast majority of Americans live and die.
The cellular machinery that generates calcium oscillations is elaborate, involving intracellular stores of calcium, shuttling of molecules to and from the plasma membrane, and complex gating schemes of calcium channels.
Specifically, two key components of the gradient-sensing pathway are conserved between D. discoideum and neutrophils: (i) the actin polymerization machinery that generates leading-edge protrusions and (ii) the acto-myosin machinery that generates cell contractions.
The data reveal that SYNPO2 provides a link between the client-processing CASA chaperone complex and a membrane-tethering and fusion machinery that generates autophagosome membranes (Fig. 1).
The biosynthetic machinery that generates the CP (capsular polysaccharide) is absent in humans, and represents an attractive target to fight S. aureus [ 6– 8].
Whether IP3R in the PM, where they may be closely associated with the signaling machinery that generates IP3, respond differently to intracellular IP3R when cells are stimulated is another issue that needs to be resolved.
The retina contains the autonomous clock machinery that generates a variety of self-sustained biochemical and cellular rhythms, allowing it to measure time and predict the 24 h changes in the ambient light conditions [ 1, 3, 4].
The spliceosome is a conserved and versatile ribonucleoprotein machinery that generates the mature mRNA by splicing the exons via precise excision of the introns at the donor and acceptor sites [ 1, 2].
Though distributed throughout the cell, the actin cytoskeleton is concentrated along the periphery of the cell underneath the membrane, particularly in Dictyostelium, and is the molecular machinery that generates cellular shape changes during cell division and chemotaxis.
