In this organism, an elegant 'self-reinforcing loop' model explains the specificity of heterochromatin formation based on the role of the RNAi machinery (reviewed in [7] [9]).
Synergy between proteins in splicing may reflect cooperative binding to a functional element(s), or multiple, simultaneous interactions between the activators and other components of the splicing machinery (reviewed in [43]).
Eukaryotic cells have to deal also with the natural ends of linear chromosomes, which are structurally similar to DSB ends but must be protected from fusion, degradation and recognition by the checkpoint machinery (reviewed in [5] [7]).
In contrast, there are reports linking p53 phosphorylation by DNA-PK to cellular death machinery (reviewed in [ 81]).
However, a growing body of evidence points towards a more dynamic and regulatory role for this machinery (reviewed in [ 1- 4]).
The KMN network complex (an acronym for Knl-1, Mis12, Ndc80) has emerged as a crucial components of such machinery (reviewed in Cheeseman and Desai, 2008).
Recently, it has been reported that numerous miRNAs are involved in the silencing of components of the epigenetic machinery (reviewed in [ 42]).
Formation of the replisome occurs at multiple origins of replication and is a stepwise process co-ordinated by the cell cycle control machinery (reviewed in [ 1]).
In E. coli, removal of RNA Pol from damaged DNA is performed during transcription coupled repair by the Mfd helicase, which also attracts the nucleotide excision repair machinery (reviewed in Selby and Sancar, 1994).
The sorting and degradation of components of various evolutionary conserved signaling pathways, such as EGFR, Hedgehog, or Wnt receptors, as well as Notch and its ligand Delta were shown to depend on the ESCRT machinery (reviewed in [ 45]).
